Fig. 2
From: A novel DNA/histone H4 peptide complex detects autoantibodies in systemic lupus erythematosus sera
PK/H4 as a probe to detect antibodies in sera. PK/H4 complexes or pDNA (20 μg/ml) were used to coat polystyrene plates; diluted sera were incubated on plates and bound antibodies detected by anti-IgG antibodies. The PK/H4 complexes (a), but not the uncomplexed pDNA (b), are able to discriminate normal healthy subjects (NHS), systemic lupus erythematosus patients (SLE), and disease controls (DC). Sensitivity and specificity evaluated by the ROC curves are reported in c PK/H4 complex and d uncomplexed pDNA