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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Suppression of lupus nephritis and skin lesions in MRL/lpr mice by administration of the topoisomerase I inhibitor irinotecan

Fig. 4

Decreased anti-double-stranded DNA (dsDNA) IgM in MRL/lpr mice treated with low-dose irinotecan (Irino). MRL/lpr mice receiving saline (n = 7), 25 mg/kg irinotecan (n = 6), or 1 mg/kg irinotecan (n = 6) were sacrificed at 18 weeks of age. MRL/MpJ mice treated with saline (n = 7) were used as controls (Ctrl). a Number of IgG- and IgM-secreting cells in the spleen determined by enzyme-linked immunosorbent spot assay. b Plasma levels of total IgG and IgM and c anti-dsDNA-specific IgG and IgM were measured by enzyme-linked immunosorbent assay. In (a), each symbol represents an individual mouse; bars show mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, versus saline-treated MRL/lpr mice by one-way analysis of variance with Bonferroni post hoc test

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Arthritis Research & Therapy

ISSN: 1478-6362

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