Fig. 3

Association of Th1 chemokines with clinical disease activity in ueRA. Orthogonal projection to latent structures (OPLS) column loading plot depicting the association between CXCL10 (a), CXCL9 (c) or CXCL11 (d) (y variables) and clinical disease activity measures, age, and symptom duration (x variables) in the patients with ueRA (n = 43). x variables represented by bars pointing in the same direction as the chemokine are positively associated, whereas variables with bars pointing in the opposite direction are inversely related to the respective chemokine. A negative Q2 value in (c) and (d) indicate that these OPLS models are not predictive. b The correlations of CXCL10 with clinical disease activity measures in ueRA patients (Spearman rank correlation test; r). *P ≤ 0.05, **P ≤ 0.01. CDAI Clinical Disease Activity Index, CRP C-reactive protein, DAS28 Disease Activity Score in 28 joints, ESR erythrocyte sedimentation rate, SJC swollen joint counts, TJC tender joint counts