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Table 2 Allele frequencies classified according to the third hypervariable region in controls and SSc patients

From: Characterization of the HLA-DRβ1 third hypervariable region amino acid sequence according to charge and parental inheritance in systemic sclerosis

 

Controls

SSc

  

HVR region

n (%)

n (%)

p value

OR (95% CI)

1

68 (18.4)

34 (14.0)

0.160

0.73 (0.46–1.14)

2

44 (11.9)

24 (9.9)

0.447

0.82 (0.48–1.38)

3

3 (0.8)

1 (0.4)

  

4

58 (15.7)

21 (8.7)

0.012

0.51 (0.30–0.87)

5

36 (9.7)

43 (17.8)

0.004§

2.00 (1.25–3.23)

6

0 (0.0)

1 (0.4)

 

7

34 (9.2)

25 (10.3)

0.640

1.14 (0.66–1.96)

8

4 (1.1)

8 (3.3)

  

9

48 (13.0)

29 (12.0)

0.718

0.91 (0.56–1.49)

10

4 (1.1)

2 (0.8)

  

11

8 (2.1)

16 (6.6)

0.006#

3.20 (1.35–7.61)

12

1 (0.3)

0 (0.0)

 

13

5 (1.3)

6 (2.5)

  

14

6 (1.6)

4 (1.7)

  

15

41 (11.1)

26 (10.7)

0.896

0.97 (0.57–1.63)

16

3 (0.8)

0 (0.0)

 

17

7 (1.9)

2 (0.8)

  

All

370

242

  
  1. Third HVR overall distribution, SSc patients versus controls, p = 0.007
  2. § p c = 0.032
  3. # p c = 0.048
  4. SSc systemic sclerosis, HVR hypervariable region, OR odds ratio, CI confidence interval, p c p value corrected for multiple comparisons