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Table 3 DQβ1 hypervariable region and charge, amino acids 70–77a

From: Characterization of the HLA-DRβ1 third hypervariable region amino acid sequence according to charge and parental inheritance in systemic sclerosis

 

Amino acid position

Overall charge

Allele

70

71

72

73

74

75

76

77

 

05:01/2/3

G

A

R

A

S

V

D

R

+1

06:01/4/9/11, 03:01/2/3

R

T

E

T

0

06:02/3/11/16

T

E

L

T

−1

02:01/2

R

K

A

+3b

04:01/2

E

D

T

−2

  1. aAmino acids that differ from the consensus (alleles on the first line) by charge are presented in bold. Sequences encoded by uncommon alleles not present in our study populations are not included
  2. bAmong SSc patients with DQβ1 + 3 charge, eight were inherited paternally and 31 inherited maternally (p corrected = 0.001)