From: Population-specific association between ABCG2 variants and tophaceous disease in people with gout
ABCG2 variant | Risk allele | All participants (n = 1778) | Non-Polynesian ancestry (n = 927) | Māori or Pacific ancestry (n = 851) | Eastern Polynesian ancestry (n = 464) | Western Polynesian ancestry (n = 387) | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Allelic OR (95% CI) | P | Allelic OR (95% CI) | P | Allelic OR (95% CI) | P | Allelic OR (95% CI) | P | Allelic OR (95% CI) | P | |||
rs2231142 | T | Unadjusted | 1.24 (1.02–1.51) | 0.033 | 0.97 (0.73–1.28) | 0.80 | 1.50 (1.14–1.99) | 0.004 | 1.28 (0.84–1.96) | 0.25 | 1.71 (1.07–2.72) | 0.017 |
Adjusted for age, sex, ancestrya | 1.30 (1.06–1.58) | 0.012 | 0.99 (0.74–1.31) | 0.93 | 1.51 (1.14–2.01) | 0.004 | 1.24 (0.81–1.91) | 0.32 | 1.79 (1.12–2.87) | 0.015 | ||
Adjusted for age, sex, ancestrya, highest recorded urate, serum creatinine and disease duration | 1.16 (0.94–1.43) | 0.17 | 0.97 (0.72–1.30) | 0.83 | 1.37 (1.01–1.85) | 0.042 | 0.91 (0.57–1.45) | 0.70 | 1.66 (1.01–2.75) | 0.048 | ||
rs10011796 | T | Unadjusted | 1.33 (1.01–1.74) | 0.040 | 1.16 (0.81–1.66) | 0.41 | 1.44 (0.94–2.20) | 0.093 | 0.87 (0.52–1.46) | 0.60 | 3.76 (1.61–8.77) | 0.002 |
Adjusted for age, sex, ancestrya | 1.31 (0.997–1.72) | 0.052 | 1.18 (0.83–1.69) | 0.36 | 1.45 (0.95–2.22) | 0.089 | 0.87 (0.52–1.47) | 0.61 | 3.75 (1.60–8.77) | 0.002 | ||
Adjusted for age, sex, ancestrya, highest recorded urate, serum creatinine and disease duration | 1.25 (0.94–1.65) | 0.13 | 1.12 (0.77–1.62) | 0.55 | 1.39 (0.88–2.18) | 0.16 | 0.82 (0.47–1.43) | 0.49 | 3.23 (1.35–7.76) | 0.009 |