Table 5 ABCG2 analysis in Māori or Pacific participants who had at least three Polynesian grandparents, according to tophus status
From: Population-specific association between ABCG2 variants and tophaceous disease in people with gout
ABCG2 variant | Risk allele | Māori or Pacific ancestry (n = 689) | Eastern Polynesian ancestry (n = 323) | Western Polynesian ancestry (n = 366) | ||||
|---|---|---|---|---|---|---|---|---|
Allelic OR (95% CI) | P | Allelic OR (95% CI) | P | Allelic OR (95% CI) | P | |||
rs2231142 | T | Unadjusted | 1.77 (1.30–2.42) | <0.001 | 1.65 (0.98–2.78) | 0.059 | 1.77 (1.10–2.87) | 0.020 |
Adjusted for age and sex | 1.76 (1.28–2.42) | <0.001 | 1.60 (0.95–2.69) | 0.077 | 1.86 (1.14–3.04) | 0.013 | ||
Adjusted for age, sex, highest recorded urate, serum creatinine and disease duration | 1.63 (1.17–2.28) | 0.004 | 1.29 (0.74–2.26) | 0.37 | 1.70 (1.01–2.86) | 0.045 | ||
rs10011796 | T | Unadjusted | 1.73 (1.04–2.88) | 0.036 | 0.90 (0.47–1.69) | 0.73 | 4.61 (1.73–12.26) | 0.002 |
Adjusted for age and sex | 1.74 (1.04–2.91) | 0.034 | 0.91 (0.48–1.73) | 0.78 | 4.58 (1.72–12.22) | 0.002 | ||
Adjusted for age, sex, highest recorded urate, serum creatinine and disease duration | 1.72 (1.002–2.95) | 0.049 | 0.89 (0.45–1.77) | 0.75 | 3.90 (1.42–10.68) | 0.008 | ||