Fig. 2

Representative screen shots from the University of California Santa Cruz Genome Browser show functional elements within neutrophil genomes. Black horizontal bar (top) represents the linkage disequilibrium (LD) blocks of the corresponding genome-wide association study single nucleotide polymorphism (SNP). Black horizontal bars between individual tracks represent H3K27ac and H3K4me1 peak regions generated from chromatin immunoprecipitation-sequencing (ChIP-Seq) data. Gray bars at the bottom of each image represent the transcription factor ChIP-seq of 161 factors from ENCODE with factorbook motifs. a LD block of rs755622 in neutrophils. Note there are expressed genes within this LD block, and the LD block contains H3K27ac and H3K4me1 regions with multiple potential transcription factor binding site (TFBS) within those regions. b LD block of rs2900180 in neutrophils. Note that there is one gene, the tumor necrosis factor receptor-associated factor (TRAF1), which is expressed within this LD block. This LD block also contains both H3K27ac and H3K4me1 peak regions with multiple TFBS within those regions. Potential active enhancers (region containing both H3K27ac and H3K4me1 peak regions) are highlighted in red. MIF macrophage inhibitory factor