Fig. 1

Integrative drug-repurposing analysis. Fourteen signatures of SLE were obtained from 14 different datasets. Each signature was queried on the Lincscloud database and a set of drugs and knock-down and knock-in genes was obtained with similarity scores. The median similarity score and empirical p values were calculated to select significant results across all datasets. Bottom: summary interpretation of the positively and negatively correlated results. NCBI GEO National Center for Biotechnology Information Gene Expression Omnibus, SLE systemic lupus erythematosus