Support for phosphoinositol 3 kinase and mTOR inhibitors as treatment for lupus using in-silico drug-repurposing analysis

Table 2 Significant knock-down and knock-in genes obtained

Score	Type of experiment	Genes
+	Knock-in	IFNB1, IFNG, CD40, BCL10, KLF6, LYN, TIRAP
+	Knock-down	CLCN3, PPP1R14B, LMNB2, TBX2, PMM2, MYC, ATP6V1F, MAX, PEPD, PUF60, PHB2, AKR1A1, BTG1, ABHD2, TFDP1, PAX8, FOSL2, NT5E, RRM1, NR2F6, RAMP1, RYK, CISH, PPP2R1A, CD14, UFD1L, HTRA1, SLC35A1, TWF2, NNT, HOMER2, HS2ST1, ZNF768, GGT1, DFFB, HSPA2, PRKDC, ARPC5, NFKBIA, SLC39A8, THAP11, GSTP1, ETV1, GCAT, KIAA0907, DLX3, ELK1, PIAS4, MEOX2, GPER, NRAS, TCEB3C, KIF2C, POLR2F, CTBP2, CHAF1B, CEP55, HOOK2, ZNF8, NDUFB7, NISCH, HOXC10, AQP12A, YES1, PSMD5, JAG1, MDH2, POLR2I, DDF1, HRAS, HDAC10, SLC25A14, MED7, HMGCR, PDXP, FDX1, NIPBL, PRKAG3, PPIA, EIF2AK3, B4GALT1, UCK2, JUN, MED4, YBX1, BUB1B, CRCP, MED1, HDAC11, SBNO1
–	Knock-down	MITF, ETFA, PIP4K2B, VRK2, SPEN, NSDHL, ZNF586, GNPDA1, SIX4, PARN, DUSP14, IQGAP1, LRRK2, GPR123, SF1, FEZ2, IPMK, SAT1, ELF4, RPTOR, EIF4E, ARL3, KARS, CSNK1A1, SPTLC2, MEN1, SNX17, VEGFC, PPP3CA, BNIP3, ERBB3, ERO1L, COPB2, SERPINC1, AK4, HLA_A, PIK3CA, PIK3C2A, IGF2R, LYPLA1, STX4, ATM, ESPL1, IGF1R, ST3GAL5, MTOR, GRN, HSP90AA1, PRPF4B, TM9SF3

Table presents knock-in genes with positive similarity score (score +), and knock-down genes with positive and negative similarity score (score –). The genes are sorted into each list by median of similarity scores across all dataset. No knock-in signatures were found with significant negative similarity score

ISSN: 1478-6362