Patients with RA (n = 75) | Patients with axSpA (n = 61) | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Flare | No flare | RR | 95% CI | P value | Flare | No flare | RR | 95% CI | P value | |
Treatment | ||||||||||
TNFi before pregnancya and discontinued at positive pregnancy test | 10 of 22 (45.5) | 5 of 53 (9.4) | 3.333 | (1.8–6.1) | 0.001* | 10 of 15 (66.7) | 14 of 46 (30.4) | 3.083 | (1.2–7.9) | 0.017* |
TNFi during first trimester | 3 of 22 (13.6) | 5 of 53 (9.4) | 1.322 | (0.5–3.5) | 0.686 | 6 of 15 (40) | 12 of 46 (26.1) | 1.593 | (0.7–3.8) | 0.340 |
GCs before pregnancy | 8 of 22 (36.4) | 17 of 53 (32.1) | 1.143 | (0.6–2.4) | 0.790 | 1 of 15 (6.7) | 4 of 46 (8.7) | 0.800 | (0.1–4.9) | 0.642 |
GCs during first trimester | 8 of 22 (36.4) | 17 of 53 (32.1) | 1.143 | (0.6–2.4) | 0.790 | 1 of 15 (6.7) | 6 of 46 (13) | 0.551 | (0.1–3.6) | 0.178 |
DMARDs before pregnancy | 10 of 22 (45.5) | 22 of 53 (41.5) | 1.120 | (0.6–2.3) | 0.801 | 3 of 15 (20) | 5 of 46 (10.9) | 1.656 | (0.6–4.6) | 0.589 |
DMARDs during first trimester | 8 of 22 (36.4) | 22 of 53 (42.5) | 0.860 | (0.4–1.8) | 0.798 | 2 of 15 (13.3) | 3 of 46 (6.5) | 1.723 | (0.5–5.6) | 0.589 |
NSAIDs before pregnancy | 2 of 22 (9.1) | 6 of 53 (11.3) | 0.838 | (0.2–2.9) | 0.568 | 3 of 15 (20) | 15 of 46 (32.6) | 0.597 | (0.2–1.9) | 0.518 |
NSAIDs during first trimester | 3 of 22 (13.6) | 6 of 53 (11.3) | 1.158 | (0.4–3.1) | 0.716 | 3 of 15 (20) | 15 of 46 (32.6) | 0.597 | (0.2–1.9) | 0.518 |
Disease activity | ||||||||||
Active disease before pregnancya | 5 of 22 (22.7) | 9 of 53 (17.0) | 1.282 | (0.6–2.9) | 0.536 | 2 of 15 (13.3) | 4 of 46 (8.7) | 1.410 | (0.4–4.8) | 0.630 |
Active disease during first trimester | 8 of 22 (36.4) | 10 of 53 (18.9) | 0.456 | (0.2–0.9) | 0.038* | 5 of 15 (33.3) | 11 of 46 (23.9) | 0.717 | (0.3–1.7) | 0.510 |
Elevated CRP before pregnancya | 3 of 22 (13.6) | 8 of 53 (15.1) | 0.584 | (0.3–1.3) | 0.282 | 1 of 15 (6.7) | 2 of 46 (4.3) | 0.724 | (0.1–3.8) | 0.718 |
Elevated CRP during first trimester | 9 of 22 (40.9) | 12 of 53 (22.6) | 0.553 | (0.2–0.7) | 0.008* | 7 of 15 (46.7) | 6 of 46 (13) | 0.280 | (0.1–0.7) | 0.006* |