Table 1 The rs6933349 genotype and smoking interaction in the risk of developing ACPA-positive RA in the EIRA and MyEIRA studies
rs6933349 | Smoking | OR (95% CI) | AP (95% CI) | Additive P value | Multiplicative P value |
|---|---|---|---|---|---|
EIRA | |||||
GG | Never | 1.0 (ref) | 0.315 (0.104–0.526) | 0.00340 | 0.022 |
GG | Current | 2.21 (1.74–2.82) | |||
GA/AA | Never | 0.91 (0.72–1.15) | |||
GA/AA | Current | 3.10 (2.38–4.05) | |||
EIRA | |||||
GG | Never | 1.0 (ref) | 0.216 (0.04–-0.39) | 0.01600 | 0.056 |
GG | Ever | 1.68 (1.39–2.04) | |||
GA/AA | Never | 0.91 (0.72–1.15) | |||
GA/AA | Ever | 2.03 (1.66–2.49) | |||
MyEIRA | |||||
GG | Never | 1.0 (ref) | 0.62 (0.29–0.96) | 0.00027 | 0.035 |
GG | Ever | 1.94 (1.30–2.90) | |||
GA/AA | Never | 0.99 (0.78–1.26) | |||
GA/AA | Ever | 5.14 (2.31–11.40) | |||