Fig. 5

Compound 968, a GLS1 inhibitor, suppresses the proliferation of RA-FLS. a RA-FLS were cultured with or without compound 968 and quantified using the WST-8 assay (n = 3). Each experiment was performed in quintuplicate. Bars indicate mean ± SEM. *P < 0.05, versus control by Welch’s t test. b RA-FLS were cultured with various concentrations of compound 968 for 96 h. Cell proliferation was analyzed using the BrdU assay (n = 6). Each experiment was performed in quintuplicate. Bars indicate mean ± SEM. *P < 0.05, **P < 0.01, versus control