Fig. 4From: Early blockade of joint inflammation with a fatty acid amide hydrolase inhibitor decreases end-stage osteoarthritis pain and peripheral neuropathy in miceProphylactic URB597 inhibits demyelination of joint nerves 14 days after MIA injection. Representative electron micrographs of axons found in saphenous nerves taken at day 14 from animals with a (a) saline-injected knee, (b) MIA-injected joint treated with vehicle (days 0–3) and (c) MIA-injected joint treated with URB597 (0.3 mg/kg, days 0–3). Myelin thickness is noticeably less in OA joint nerves and this demyelination is prevented by prophylactic URB597 treatment. d G-ratio calculations showing that MIA causes saphenous axonal demyelination which is prevented by URB597 treatment. Scale bar = 6 μm. *P < 0.05 one-way ANOVA with Tukey’s post-hoc test; n = 5–7. Data presented as mean ± SEM. MIA monoiodoacetateBack to article page