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Table 3 Mean (SD) cumulative levels of aggrecan fragments detected in medium after 16 days of culture

From: Coculture of bovine cartilage with synovium and fibrous joint capsule increases aggrecanase and matrix metalloproteinase activity

FFGV (ng/μg sGAG)

Condition A

Condition B

Condition C

Condition D

0.326 (0.016)

0.447 (0.036)

1.002 (0.359)

1.506 (0.359)

 

P value

Norm

   

B vs A

0.021

1.37

 

P value

Norm

  

C vs A

0.428

3.07

C vs B

0.509

2.24

 

P value

Norm

 

D vs A

0.049

4.62

D vs B

0.067

3.37

D vs C

0.744

1.50

 

ARGS-CS2 (ng/μg sGAG)

Condition A

Condition B

Condition C

Condition D

0.48 (0.036)

0.51 (0.056)

2.10 (1.608)

2.32 (1.134)

 

P value

Norm

   

B vs A

0.193

1.06

 

P value

Norm

  

C vs A

0.254

4.38

C vs B

0.255

4.12

 

P value

Norm

 

D vs A

0.032

4.83

D vs B

0.033

4.55

D vs C

0.850

1.10

 

G1-KEEE (AU/mg sGAG)

Condition A

Condition B

Condition C

Condition D

0.909 (0.604)

0.986 (1.028)

9.297 (0.781)

25.118 (13.842)

 

P value

Norm

   

B vs A

0.905

1.08

 

P value

Norm

  

C vs A

0.011

10.23

C vs B

0.016

9.43

 

P value

Norm

 

D vs A

0.119

27.63

D vs B

0.106

25.47

D vs C

0.298

2.70

 

G1–G3 (ng/μg sGAG)

Condition A

Condition B

Condition C

Condition D

15.3 (2.75)

23.6 (18.27)

9.8 (1.51)

18.6 (14.59)

 

P value

Norm

   

B vs A

0.460

1.54

 

P value

Norm

  

C vs A

0.159

0.64

C vs B

0.351

0.42

 

P value

Norm

 

D vs A

0.935

1.22

D vs B

0.199

0.79

D vs C

0.603

1.90

 
  1. Abbreviations: FFGV Total levels of FFGV fragments, Norm Normalizing mean values. Conditions: A Uninjured cartilage, B Injured cartilage, C Uninjured cartilage + synovium + joint capsule, D Injured cartilage + synovium + joint capsule
  2. Statistical (using paired samples t test) significance (P < 0.05) or trends (P < 0.1) are shown in bold
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Arthritis Research & Therapy

ISSN: 1478-6362

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