Characteristics | All SLE (n = 261) | IFN-λ1high (n = 65) | Others (n = 196) | p Value | IFN-αhigh (n = 65) | Others (n = 196) | p Value |
---|---|---|---|---|---|---|---|
Age, years, mean (SD) | 47.6 (14) | 46.3 (15) | 48.0 (14) | ns | 43.3 (15) | 49.0 (14) | 0.01 |
Ever smoker, % | 54 | 40 | 59 | 0.008 | 57 | 53 | ns |
SLAM >6, % | 49 | 52 | 48 | ns | 49 | 49 | ns |
SLEDAI >6, % | 26 | 31 | 25 | ns | 29 | 25 | ns |
SDI >0, % | 64.4 | 60 | 65 | ns | 60 | 65 | ns |
Autoantibodies, % | |||||||
Nucleosome | 44 | 55 | 40 | 0.028 | 46.5 | 43 | ns |
Ro52/SSA | 28 | 28 | 27 | ns | 41.5 | 22.5 | 0.003 |
Ro60/SSA | 40.5 | 41.5 | 40 | ns | 51 | 37 | 0.05 |
La/SSB | 21.5 | 20 | 22 | ns | 37 | 16 | 0.005 |
LA | 16 | 20 | 15 | ns | 4.5 | 20 | 0.003 |
aCL IgG | 19 | 23 | 18 | ns | 9 | 22.5 | 0.02 |
aβ2GP1 IgG | 21 | 23 | 20 | ns | 9 | 25 | 0.009 |
Triple-aPL | 15 | 18.5 | 13 | ns | 4.5 | 18 | 0.008 |
Mucocutaneous, % | |||||||
Mucocutaneous SLAM >0 | 38 | 38 | 38 | ns | 54 | 33 | 0.002 |
Reticuloendothelial, % | |||||||
Lymphadenopathy SLAM >0 | 13 | 15 | 12 | ns | 22 | 9.5 | 0.02 |
Musculoskeletal, % | |||||||
Arthritis | 17 | 15 | 18 | ns | 17 | 17.5 | ns |
Musculoskeletal SDI >0 | 13 | 4.5 | 20.5 | 0.002 | 14 | 17 | ns |
Erosive arthritis SDI >0 | 10.0 | 1.5 | 13 | 0.009 | 8 | 11 | ns |
Cardiovascular, % | |||||||
Secondary APS | 17 | 21.5 | 15 | ns | 9 | 20 | 0.058 |
VTE | 15 | 17 | 15 | ns | 6 | 18 | 0.018 |
Any vascular event | 29 | 31 | 28 | ns | 15 | 33 | 0.006 |
Renal | |||||||
Creatinine, μmol/L, mean (SD) | 87 (90) | 91 (124) | 75 (5) | ns | 70 (16) | 93 (103) | 0.003 |
GFR, ml/minute/1.73 m2, median (IQR) | 84 (67–101) | 83 (68–101) | 85(67–103) | ns | 91 (76–108) | 82 (76–108) | 0.028 |
Routine laboratory tests | |||||||
WBC, 109/L, mean (SD) | 5.2 (2.2) | 4.9 (2) | 5.4 (2.3) | ns | 4.7 (1.9) | 5.5 (2.3) | 0.02 |
Lymphocytes, 109/L, mean (SD) | 1.3 (0.7) | 1.08 (0.5) | 1.3 (0.7) | 0.003 | 1.2 (0.6) | 1.3 (0.05) | ns |
Complement | |||||||
C3, g/L, mean (SD) | 0.86 (0.24 | 0.82 (0.26) | 0.88 (0.24) | ns | 0.79 (0.28) | 0.89(0.2) | 0.004 |
C4, g/L, mean (SD) | 0.15 (0.07) | 0.14 (0.08) | 0.15 (0.07) | ns | 0.12 (0.06) | 0.16 (0.07) | 0.001 |
Medication | |||||||
Warfarin, % | 15 | 17 | 14 | ns | 5 | 18 | 0.008 |
Prednisone, months, mean (SD) | 232 (822) | 206 (390) | 241 (926) | ns | 88 (151) | 280 (940) | 0.009 |
Cytokines, % | |||||||
IL-17Ahigh | 10 | 34 | 1.5 | 0.0001 | 8 | 11 | ns |
IL-23high | 25 | 55 | 14 | 0.0001 | 35.5 | 21 | 0.026 |
IP-10high | 25 | 29 | 24 | ns | 30 | 23 | ns |