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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Targeted designed variants of alpha-2-macroglobulin (A2M) attenuate cartilage degeneration in a rat model of osteoarthritis induced by anterior cruciate ligament transection

Fig. 2

Wild-type alpha-2-macroglobulin (WT-A2M) and its variants CYT-98 and CYT-108 inhibit matrix. metalloproteinases (MMPs) (a and b) and cathepsin (d and e). MMPs and cathepsin levels peak 2 days after knee joint injury. The levels of MMPs (a) and cathepsin (d), as detected by fluorescence molecular tomography after anterior cruciate ligament transection (ACLT), peaked 2 days after surgery, indicating an early catabolic response that subsided thereafter. The mean SD region of interest signal intensities (n = 11 per group) at each time point over a 6-week period are shown (bottom) (c and f). *Compared with sham, P < 0.05. #Compared with PBS, P < 0.05

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Arthritis Research & Therapy

ISSN: 1478-6362

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