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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Targeted designed variants of alpha-2-macroglobulin (A2M) attenuate cartilage degeneration in a rat model of osteoarthritis induced by anterior cruciate ligament transection

Fig. 3

Supplemental intra-articular injection of wild-type alpha-2-macroglobulin (wt-A2M) and its variants CYT-98 and CYT-108 attenuates cartilage degeneration. a Strong Safranin O staining and a relatively smoother surface were detected in the articular cartilage from the animals treated with wt-A2M and its variants as compared to PBS-treated controls. b The Osteoarthritis Research Society International grading score indicated that cartilage damage was most severe in rats that underwent anterior cruciate ligament transection (ACLT) and PBS treatment, while cartilage in rats that underwent sham operation had the least damage. Cartilage damage was further reduced in the rats that received the high dose of the variants of A2M as compared to the rats that received the low dose of the variants of A2M. Values are the mean ± SD. #Compared with ACLT + PBS, P < 0.05; *compared with sham, P < 0.05; €compared with ACLT + A2M, P < 0.05

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Arthritis Research & Therapy

ISSN: 1478-6362

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