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Table 2 Presence of perifascicular atrophy and RIG-I staining in the muscle biopsies of patients with DM and non-DM (1) and sensitivity and specificity of atrophy and RIG-I positivity to diagnose DM (2)

From: RIG-I expression in perifascicular myofibers is a reliable biomarker of dermatomyositis

1)

 

PFA#, a

PFA (2 rows)b

RIG-Ic

   

 DM (N; %)

16 (36%)

11 (25%)

22 (50%)

   

 No DM (N; %)

13 (21%)

5 (8%)

7 (11%)

   

 p*

0.09

0.02

<0.001

   

2)

    

p (a vs b)**

p (a vs c)**

p (b vs c)**

 Sensitivity

36%

25%

50%

0.06

0.08

0.005

 Specificity

79%

92%

88%

<0.01

0.08

0.7

 Reproducibility (κ)***

 

0.37

0.51

   
  1. Healthy controls were excluded from this analysis. DM dermatomyositis, PFA perifascicular atrophy. #Perifascicular atrophy includes one or more rows of atrophic muscle fibers. *Association between bivariate variables was perfomed using Fisher’s exact test. **Sensitivity and specificity were compared using the McNemar test. ***Reproducibility was assessed using Cohen’s kappa coefficient (κ).