Inflammatory potential of diet and risk of incident knee osteoarthritis: a prospective cohort study

Table 3 Direct and indirect effects of E-DII on incident ROA and SxOA for mediation via BMI

E-DII	< 2.50	≥ 2.50
ROA	n = 894 persons	n = 892 persons
Total effect*	1.00 (ref)	1.47 (1.10, 1.97)
Direct effect	1.00 (ref)	1.36 (1.02, 1.82)
Indirect effect via BMI	1.00 (ref)	1.08 (1.04, 1.13)
Proportion of mediation via BMI	20.4%
SxOA	n = 1471 persons	n = 1469 persons
Total effect*	1.00 (ref)	1.31 (1.13, 1.51)
Direct effect	1.00 (ref)	1.16 (1.01, 1.34)
Indirect effect via BMI	1.00 (ref)	1.13 (1.09, 1.16)
Proportion of mediation via BMI	44.5%

E-DII energy-adjusted dietary inflammatory index, BMI body mass index, ROA radiographic knee osteoarthritis, SxOA symptomatic knee osteoarthritis
*Model adjusted for age (years), sex (men vs women), race (white vs non-white), total energy intake (kcal/day), education (< college vs ≥ college), yearly income level (< 50,000 US$ vs ≥ 50,000 US$), tobacco use (non-smoker vs smoker), and physical activity (PASE, continuous)

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