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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Association of biochemical markers with bone marrow lesion changes on imaging—data from the Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium

Fig. 1

Examples of change in bone marrow lesions (BML). One of the outcome measures was change in maximum size of BML per knee. A Baseline sagittal intermediate-weighted fat suppressed MRI shows a small grade 1 BML at the anterior lateral femur (arrow). B 24-month follow-up MRI shows increase in size of BML to grade 2 (arrowheads). C Another example shows a small grade 1 BML at the posterior lateral tibia at baseline (arrow). D 24-month follow-up MRI shows marked increase in tibial BML now comprising the central and posterior tibial subregions (arrows). In addition, there is a new grade 3 BML at the lateral posterior femur (arrowheads) that also involves the central lateral femur (grade 1). This knee shows an increase of number of subregions affected by any BML from 1 subregion at baseline to 4 subregions at 24 months follow-up. Increase in number of subregions affected per knee was the second outcome measure in this study

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Arthritis Research & Therapy

ISSN: 1478-6362

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