Skip to main content

Table 3 Association between short-term (0–12 months) change in biochemical markers and long-term (24 months) bone marrow lesion change

From: Association of biochemical markers with bone marrow lesion changes on imaging—data from the Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium

 

Serum CTX-I

Serum NTX-I

Serum C1M

Serum C2M

Serum C3M

Serum CRPM

Urine NTX-I

Urine CTX-II

Urinary CTX-Iα

Urinary CTX-Iβ

aSerum hsPRO-C2

BMLs

 Maximum size

1.11

P = 0.217

(0.94, 1.30)

1.01

P = 0.860

(0.86, 1.19)

1.02

P = 0.783

(0.87, 1.21)

1.02

P = 0.828

(0.84, 1.24)

1.00

P = 0.952

(0.86, 1.17)

0.98

P = 0.769

(0.84, 1.14)

0.99

P = 0.857

(0.86, 1.14)

1.02

P = 0.769

(0.88, 1.19)

0.99

P = 0.838

(0.86, 1.13)

1.09

P = 0.260

(0.94, 1.28)

0.96

P = 0.683

(0.80, 1.16)

Time-integrated concentrations

1.06

P = 0.501

(0.90, 1.24)

1.01

P = 0.937

(0.86, 1.17)

0.97

P = 0.727

(0.83, 1.14)

1.07

P = 0.429

(0.91, 1.25)

1.00

P = 0.952

(0.86, 1.17)

0.95

P = 0.520

(0.83, 1.10)

1.02

P = 0.809

(0.88, 1.17)

0.98

P = 0.819

(0.84, 1.15)

1.02

P = 0.801

(0.89, 1.17)

1.06

P = 0.478

(0.90, 1.24)

0.99

P = 0.954

(0.84, 1.18)

 Number of subregions

1.20

P = 0.026

(1.02, 1.40)

1.17

P = 0.051

(1.00, 1.37)

1.08

P = 0.375

(0.91, 1.28)

0.91

P = 0.294

(0.75, 1.09)

1.08

P = 0.347

(0.92, 1.26)

0.94

P = 0.369

(0.81, 1.08)

0.98

P = 0.823

(0.86, 1.13)

1.04

P = 0.638

(0.89, 1.21)

0.98

P = 0.784

(0.85, 1.13)

1.17

P = 0.045

(1.00, 1.36)

aMultinomial logistic regression

Time-integrated concentrations

1.06

P = 0.487

(0.90, 1.24)

1.05

P = 0.551

(0.90, 1.22)

1.10

P = 0.261

(0.93, 1.30)

1.13

P = 0.142

(0.96, 1.33)

1.06

P = 0.482

(0.91, 1.24)

0.97

P = 0.712

(0.85, 1.12)

1.02

P = 0.784

(0.89, 1.17)

1.03

0.669

(0.86, 1.21)

1.02

P = 0.750

(0.89, 1.17)

1.05

P = 0.538

(0.90, 1.23)

0.94

P = 0.444

(0.79, 1.11)

aMultinominal logistic regression

 Improvement

 No change

 Worsening 1 subregion

 Worsening 2 + subregions

         

1.13 (0.71, 1.79), P = 0.602

Ref

0.73 (0.54, 0.98), P = 0.039

0.78 (0.71, 1.96), P = 0.527

  1. BMLs bone marrow lesions, OR odds ratio, 95% CI 95% confidence interval, CTX-I serum C-terminal crosslinked telopeptide of type I collagen, NTX-I serum crosslinked N-telopeptide of type I collagen, CTX-II urinary CTX-Iα and CTX-Iβ, urinary NTX-I, urinary C-terminal crosslinked telopeptide of type II collagen, C1M, C2M, C3M serum type I, type II and type III collagen degradation mediated by matrix metalloproteinase (MMP) cleavage, hsPRO-C2 serum propeptide of type IIb collagen, CRPM serum metabolite of C-reactive protein
  2. aMultinomial logistic regression analysis conducted as proportionality of odds assumption was not satisfied
Back to article page

Arthritis Research & Therapy

ISSN: 1478-6362

Contact us