Fig. 2

The expression of serum protein profiles in patients with SSc with different pulmonary complications using the high-throughput antibody microarray. A The heatmap of the log2 (fold change) of the 125 differentially expressed proteins in the microarray test. A total of 20 participants were equally divided into four groups, including the SSc with PAH (SSc-PAH), SSc with ILD (SSc-ILD), SSc without PAH and ILD (SSc-nonPAH-nonILD), and HC groups. A protein was considered differentially expressed when the p-value was < 0.05 and the fold change was > 1.2 or < 0.8. B Comparison of the four selected differentially expressed protein (CD40, SOST, fibronectin, and calcitonin) levels between each subgroup of patients with SSc and the HCs