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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Lipoxygenase-derived oxylipins are enriched in anti-citrullinated protein antibody (ACPA)-positive individuals at risk for developing rheumatoid arthritis

Fig. 2

Differences in oxylipin profiles in various pre-clinical RA stages. (A) Oxylipins derived from arachidonic Acid (AA), linoleic Acid (LA), dihomo-y-linolenic acid (DGLA), alpha-linolenic acid (ALA), eicosapentaenoic Acid (EPA) and Docosahexaenoic acid (DHA) in ACPA- FDR and ACPA+ FDR. Differences determined with Wilcoxon rank-sum test. (B) Ordered oxylipins by log2 fold change (vs ACPA- FDR) colored by derived fatty acid (legend). (C) Log2 fold change in Progressors (vs ACPA- FDR) or ACPA+ FDR (vs ACPA- FDR) categorized by log2 fold change > 1.5 (dotted lines). Pie charts are representative of the proportion of oxylipins based on the FA from which they are derived. Differences in proportion measured with chi-square test. The ratio between AA-derived oxylipins and EPA-derived oxylipins in ACPA+ FDR and ACPA+ Progressors. Differences determined with Wilcoxon rank-sum test

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Arthritis Research & Therapy

ISSN: 1478-6362

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