Fig. 3

LOX-derived oxylipins are increased in ACPA+ FDR and ACPA+ Progressors. (A) Omega-6 (ω6) and omega-3 (ω3) oxylipins derived from LOX (lipoxygenase), COX (cyclooxygenase), or CYP (cytochrome P450) pathways in ACPA- FDR, ACPA+ FDR and ACPA+ Progressor. Differences determined with Wilcoxon rank-sum test. Trend lines are drawn through the median values for each group (B) Arachidonic acid lipoxygenase pathway annotated by known steps of synthesis to derive oxylipins. Undetected oxylipins are grey, while detected are colored in black. Within each cell, there is a color gradient from left to right, based on the expression relative in ACPA+ FDR (left) and ACPA+ Progressors (right) relative to controls (log2 fold change)