Table 3 Clinical parameters in SLE patients with different 5-HTTLPR genotypes

Female [n(%)]

22 (84.60%)

23 (92.00%)

0.15

0.70^a

Age (year)

30.12 ± 10.36

29.40 ± 9.06

0.26

0.79^b

Education (year)

13.04 ± 3.80

13.08 ± 2.97

 − 0.04

0.97^b

SLEDAI scores

9.85 ± 6.73

8.92 ± 7.02

0.48

0.63^b

Disease activity (SLEDAI) [n (%)]

0.19

0.67^c

 None (0–4)

8 (30.80%)

9 (36.00%)

 Mild (5–9)

6 (23.10%)

6 (24.00%)

 Moderate (10–14)

5 (19.20%)

4 (16.00%)

 Severe (> 15)

7 (26.90%)

6 (24.00%)

HAMD scores

8.38 ± 3.72

7.52 ± 4.84

0.72

0.48^b

HAMA scores

6.46 ± 4.25

5.04 ± 4.15

1.21

0.23^b

Depression/anxiety status [n (%)]

 Depression (≥ 7)

17 (65.40%)

12 (48.00%)

1.57

0.21^d

 Anxiety (≥ 7)

11 (64.70%)

6 (35.30%)

1.92

0.17^d