Regulatory T and B cells in pediatric Henoch–Schönlein purpura: friends or foes?

Filleron, Anne; Cezar, Renaud; Fila, Marc; Protsenko, Nastassja; Van Den Hende, Kathleen; Jeziorski, Eric; Occean, Bob; Chevallier, Thierry; Corbeau, Pierre; Tran, Tu Anh

doi:10.1186/s13075-024-03278-w

Arthritis Research & Therapy

Table 3 Blood count and lymphocyte subpopulations at inclusion in groups A, B, and C

From: Regulatory T and B cells in pediatric Henoch–Schönlein purpura: friends or foes?

Patient groups	A	B	C	p value global	Holm adjusted p value
Patient groups	A	B	C	p value global	A vs. B	A vs. C	B vs. C
Number of subjects	30	30	40
Hemoglobin, g/dl (1/0/13)^a	12.3 [11.8; 12.9]	12.75 [12.1; 13.3]	12.6 [11.9; 13.2]	0.2421	0.2159	0.5795	0.5795
Platelets/mm³ (1/0/13)^a	367 [323; 410]	313.5 [274; 335]	295 [255; 367]	0.0002	0.0003	0.0003	0.8925
WBC/mm³ (1/0/13)^a	9.2 [6.61; 12.16]	7.55 [6.3; 8.78]	6.81 [5.93; 8.3]	0.0153	0.0103	0.0103	0.9485
Neutrophils/mm³ (3/0/13)^a	4.66 [3.49; 6.59]	3.44 [2.47; 4.42]	3.31 [2.25; 4.64]	0.0133	0.0069	0.0103	0.8435
Monocyte/mm³ (3/0/13)^a	0.68 [0.52; 0.99]	0.59 [0.47; 0.7]	0.52 [0.44; 0.6]	0.0174	0.9187	0.6018	0.6018
Lymphocytes/mm³ (3/0/13)^a	2.85 [1.99; 3.94]	2.72 [2.26; 3.4]	2.76 [2.29; 3.42]	0.6895	1.0	1.0	1.0
CD3⁺/mm³ (2/3/3)^a	1440 [1179; 1958.5]	1828 [1504; 2534]	1458 [1184; 2074]	0.1329	0.3510	0.9476	0.3510
% CD3⁺ (1/1/3)^a	74.29 [68.16; 77.7]	75.44 [70.54; 79.54]	74.02 [70.25; 77.15]	0.5626	0.7962	0.7962	0.5803
CD4⁺/mm³ (2/3/4)^a	901.5 [666; 1187.5]	1136 [795; 1335]	897 [672.5; 1312]	0.2268	0.4205	0.8133	0.4205
% CD4⁺ (1/1/4)^a	41.49 [38.35; 47.69]	44.78 [38.57; 49.52]	45.57 [40.85; 50.15]	0.4827	1.0	1.0	1.0
CD8⁺/mm³ (2/3/4)^a	458 [395; 666.5]	568 [477; 783]	515 [379.5; 668]	0.2212	0.7008	0.7008	0.5113
% CD8⁺ (1/1/4)^a	22.45 [19.86; 29.96]	24.91 [21.69; 29.9]	24.29 [21.78; 25.87]	0.5112	1.0	1.0	1.0
CD19⁺/mm³ (2/4/4)^a	351 [253.5; 583]	419 [210; 512]	364.5 [273; 449]	0.9401	1.0	1.0	1.0
% CD19⁺ (1/2/4)^a	18 [14.48; 21.02]	15.63 [12.52; 19.19]	17.37 [13.01; 21.21]	0.3043	0.2898	0.9408	0.2898
CD3⁻CD56⁺/mm³ (2/4/4)^a	78 [54; 143]	122.5 [71; 219]	88 [69.5; 129]	0.3068	0.6492	0.8993	0.6492
% CD3⁻CD56⁺ (1/2/4)^a	4.23 [2.71; 5.77]	4.86 [2.7; 8.26]	4.31 [2.66; 6.37]	0.8390	1.0	1.0	1.0
Tregs/mm³ (4/4/8)^a	50.01 [35.09; 84.48]	50.53 [29.1; 68.44]	39.44 [20.95; 73.82]	0.3871	0.4678	0.3192	0.7101
% Tregs (3/1/4)^a	6.53 [4.24; 9.21]	4.33 [3.6; 5.66]	4.45 [3.01; 6.6]	0.0049	0.0016	0.0029	0.6253
% CD4⁺CD25⁺ (3/5/7)^a	6.72 [5.47; 9.16]	5.96 [4.51; 7.64]	5.72 [4.6; 9.32]	0.3876	1.0000	1.0000	1.0000
% CD4⁺ central memory (3/7/7)^a	15.13 [8.98; 22.59]	13.38 [7.58; 20.67]	9.72 [7.19; 13.76]	0.0899	0.4043	0.0356	0.4043
% CD4⁺ effector memory (3/7/7)^a	16.38 [11.77; 21.97]	14.17 [8.78; 17.42]	15.79 [11.68; 19.4]	0.3624	1.0000	1.0000	1.0000
% CD4⁺ naives (3/7/7)^a	58.47 [48.59; 64.28]	61.65 [56.15; 64.71]	61.78 [54.65; 64.29]	0.3546	0.7739	0.5977	0.7739
% CD8⁺ central memory (3/7/6)^a	5.78 [4.08; 11.75]	7.14 [3.96; 12.15]	7.61 [5.07; 10.12]	0.9066	1.0000	1.0000	1.0000
% CD8⁺ effector memory (3/7/6)^a	8.39 [5.15; 11.98]	8.44 [3.72; 15.83]	10.5 [6.06; 15.83]	0.3803	0.7549	0.4377	0.5732
% CD8⁺ naives (3/7/6)^a	67.55 [58.77; 75.82]	68.43 [57.08; 75.67]	67.68 [54.28; 74.17]	0.5280	0.8284	0.4365	0.4871
% Bregs (11/6/17)^a	6.47 [5.34; 8.70]	5.86 [4.45; 9.27]	6.90 [5.53; 9.39]	0.7001	1.0000	1.0000	1.0000

Data are shown as median (interquartile range q1; q3)
CM Central memory, EM Effector memory, tEM Terminally differentiated, SM Switched memory, NSM Non-switched memory, DN Double-negative
^aMissing data respectively for n patients in groups A, B, and C

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