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Table 2 Association of alcohol intake phenotypes with serum urate level, hyperuricaemia, and gout

From: Interaction of genetic variation at ADH1B and MLXIPL with alcohol consumption for elevated serum urate level and gout among people of European ethnicity

Group

Alcohol intake (units/week)

Association with serum urate (μmol/L)

Association with hyperuricaemia

Association with gout

β

SE

Î’

P-value

OR

95% CI

P-value

OR

95% CI

P-value

All participants

 

N = 345,339

N = 345,339

N = 350,057

All alcohol

0.49

0.01

0.12

< 1.00 × 10−300

1.015

1.014, 1.015

< 1.00 × 10−300

1.013

1.013, 1.014

1.16 × 10−173

Beer

0.75

0.01

0.12

< 1.00 × 10−300

1.022

1.021, 1.023

< 1.00 × 10−300

1.023

1.021, 1.024

3.86 × 10−285

Spirits

0.45

0.02

0.03

1.41 × 10−104

1.013

1.011, 1.016

9.14 × 10−39

1.006

1.002, 1.010

0.001

Wine

0.33

0.01

0.06

< 1.00 × 10−300

1.009

1.008, 1.010

6.29 × 10−22

1.004

1.002, 1.006

3.62 × 10−7

Men

 

N = 163,469

N = 163,469

N = 167,653

All alcohol

0.51

0.01

0.16

< 1.00 × 10−300

1.015

1.014, 1.015

< 1.00 × 10−300

1.014

1.013, 1.015

7.37 × 10−172

Beer

0.74

0.01

0.17

< 1.00 × 10−300

1.021

1.021, 1.022

< 1.00 × 10−300

1.023

1.021, 1.024

2.04 × 10−281

Spirits

0.40

0.03

0.03

1.74 × 10−51

1.011

1.009, 1.014

1.99 × 10−27

1.006

1.002, 1.009

0.002

Wine

0.31

0.01

0.07

8.33 × 10−217

1.009

1.008, 1.009

1.23 × 10−103

1.004

1.002, 1.006

6.79 × 10−7

Women

 

N = 181,870

N = 181,870

N = 182,404

All alcohol

0.47

0.01

0.10

< 1.00 × 10−300

1.018

1.016, 1.020

3.71 × 10−76

1.010

1.004, 1.017

0.002

Beer

0.95

0.03

0.06

1.26 × 10−197

1.041

1.036, 1.046

1.55 × 10−53

1.029

1.012, 1.045

7.05 × 10−4

Spirits

0.77

0.04

0.04

4.88 × 10−103

1.031

1.026, 1.037

5.31 × 10−30

1.021

1.006, 1.038

0.01

Wine

0.40

0.01

0.08

< 1.00 × 10−300

1.013

1.011, 1.015

3.53 × 10−33

1.006

0.998, 1.014

0.12

  1. Abbreviations: β unstandardised beta coefficient per unit/week increase in alcohol intake, SE Otandard error, B standardised beta coefficient per unit/week increase in alcohol intake, OR Odds ratio per unit/week increase in alcohol intake, 95% CI 95% confidence interval
  2. Adjusted for age, gender (all participants only), Townsend deprivation index, BMI, diuretics use, eGFR, high cholesterol, hypertension, cardiac problem, peripheral vascular disease, stroke, diabetes mellitus, smoking status, other alcoholic beverage types (beer/spirits/wine/other) intake (excluding all alcohol intake analyses), meat intake, fish intake, coffee intake, tea intake, fruit intake, vegetable intake, bread intake, cereal intake, and cheese intake
  3. Bonferroni-corrected experiment-wide significance for each analysis: P < 0.01