Interaction of genetic variation at ADH1B and MLXIPL with alcohol consumption for elevated serum urate level and gout among people of European ethnicity

Table 5 Interaction terms between gout-associated SNPs and all alcohol intake (units/week) for gout. Significant interactions highlighted in bold

Locus	SNP	Gout risk allele	All participants (N = 458,367)				Men (N = 209,493)				Women (N = 248,874)
Locus	SNP	Gout risk allele	Obs, %	IT (OR)	95% CI	P-value	Obs, %	IT (OR)	95% CI	P-value	Obs, %	IT (OR)	95% CI	P-value
GCKR	rs1260326	T	76.4%	1.000	0.998, 1.002	0.80	80.0%	1.000	0.998, 1.002	0.78	73.3%	0.996	0.984, 1.008	0.51
*ADH1B*	rs1229984	T	76.4%	1.012	1.008, 1.016	8.15 × 10⁻⁹	80.0%	1.011	1.007, 1.016	6.07 × 10⁻⁸	73.3%	1.027	1.006, 1.048	0.01
MLXIPL	rs6460047	T	76.0%	0.999	0.994, 1.003	0.60	79.6%	0.999	0.994, 1.004	0.68	72.9%	0.983	0.959, 1.008	0.18
NFAT5	rs113441031	T	75.8%	0.998	0.997, 1.000	0.08	79.5%	0.998	0.997, 1.000	0.09	72.8%	1.000	0.987, 1.013	0.99

Abbreviations: SNP Single-nucleotide polymorphism, Obs Observations (%), IT Interaction term for SNP (≥one urate-raising allele vs. none) × all alcohol intake (units/week), OR Odds ratio, 95% CI 95% confidence interval
Adjusted for age, gender (all participants only), Townsend deprivation index, BMI, diuretics use, eGFR, high cholesterol, hypertension, cardiac problem, peripheral vascular disease, stroke, diabetes mellitus, smoking status, meat intake, fish intake, coffee intake, tea intake, fruit intake, vegetable intake, bread intake, cereal intake, and cheese intake
Bonferroni-corrected experiment-wide significance for each analysis: P < 0.01

ISSN: 1478-6362