Table 6 Genotype-stratified association analysis of ADH1B or MLXIPL with alcohol intake for serum urate level (μmol/L)

All participants

N = 26,472

N = 382,105

ADH1B

T−

N = 387,563

1

-

10.35 (0.38)

3.06 × 10⁻¹⁶⁰

rs1229984

T+

N = 21,014

1.07 (1.46)

0.46

16.53 (0.56)

1.42 × 10⁻¹⁹²

1.49 × 10⁻⁴⁷

N = 26,328

N = 380,042

MLXIPL

T−

N = 17,344

1

-

8.58 (1.78)

1.38 × 10⁻⁶

rs6460047

T+

N = 389,026

2.67 (1.75)

0.13

13.38 (1.72)

7.30 × 10⁻¹⁵

3.99 × 10⁻²⁵

Men

N = 8937

N = 174,876

ADH1B

T−

N = 174,229

1

-

16.32 (0.70)

7.26 × 10⁻¹²¹

rs1229984

T+

N = 9584

0.68 (2.83)

0.81

23.64 (0.94)

1.06 × 10⁻¹³⁸

3.65 × 10⁻²⁸

N = 8889

N = 173,949

MLXIPL

T−

N = 7699

1

-

10.99 (3.27)

7.91 × 10⁻⁴

rs6460047

T+

N = 175,139

−0.16 (3.26)

0.96

16.72 (3.20)

1.70 × 10⁻⁷

1.06 × 10⁻¹⁴

Women

N = 17,535

N = 207,229

ADH1B

T−

N = 213,334

1

-

8.46 (0.44)

1.28 × 10⁻⁸²

rs1229984

T+

N = 11,430

0.50 (1.61)

0.75

13.50 (0.68)

8.96 × 10⁻⁸⁹

6.59 × 10⁻²¹

N = 17,439

N = 206,093

MLXIPL

T−

N = 9645

1

-

8.66 (2.02)

1.80 × 10⁻⁵

rs6460047

T+

N = 213,887

3.89 (1.98)

0.05

12.62 (1.94)

8.43 × 10⁻¹¹

7.04 × 10⁻¹²