Table 7 Genotype-stratified association analysis of ADH1B and alcohol intake for hyperuricaemia

All participants

N = 26,472

N = 382,105

ADH1B

T−

N = 387,563

1

-

1.48 (1.40, 1.56)

1.65 × 10⁻⁴³

rs1229984

T+

N = 21,014

1.10 (0.89, 1.35)

0.39

1.86 (1.73, 2.00)

1.47 × 10⁻⁶³

4.09 × 10⁻²⁰

Men

N = 8937

N = 174,876

ADH1B

T−

N = 174,229

1

-

1.67 (1.56, 1.79)

3.39 × 10⁻⁵⁰

rs1229984

T+

N = 9584

1.08 (0.83, 1.41)

0.55

2.11 (1.94, 2.29)

5.07 × 10⁻⁶⁷

2.20 × 10⁻¹⁷

Women

N = 17,535

N = 207,229

ADH1B

T−

N = 213,334

1

-

1.29 (1.17, 1.42)

1.45 × 10⁻⁷

rs1229984

T+

N = 11,430

1.06 (0.75, 1.49)

0.76

1.59 (1.37, 1.85)

2.57 × 10⁻⁹

0.001