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Table 8 Genotype-stratified association analysis of ADH1B and alcohol intake for gout

From: Interaction of genetic variation at ADH1B and MLXIPL with alcohol consumption for elevated serum urate level and gout among people of European ethnicity

Group

Locus SNP

Gout risk allele

N

No alcohol intake

Any alcohol intake

OR (95% CI)

P-value

OR (95% CI)

P-value

Pdifference

All participants

  

N = 26,738

N = 387,034

 

ADH1B

T−

N = 392,329

1

-

1.39 (1.22, 1.58)

6.88 × 10−7

 

rs1229984

T+

N = 21,443

0.95 (0.56, 1.59)

0.84

2.53 (2.17, 2.96)

7.17 × 10−32

3.42 × 10−36

Men

  

N = 9114

N = 179,232

 

ADH1B

T−

N = 178,369

1

-

1.65 (1.42, 1.91)

6.09 × 10−11

 

rs1229984

T+

N = 9977

0.90 (0.48, 1.69)

0.75

3.01 (2.53, 3.58)

3.81 × 10−35

1.06 × 10−33

Women

  

N = 17,624

N = 207,802

 

ADH1B

T−

N = 213,960

1

-

0.78 (0.60, 1.01)

0.06

 

rs1229984

T+

N = 11,466

1.02 (0.41, 2.55)

0.97

1.42 (0.93, 2.17)

0.10

0.001

  1. Abbreviations: SNP Single-nucleotide polymorphism, OR Odds ratio of gout compared to reference group (no gout risk allele × no alcohol intake), 95% CI 95% confidence interval, Pdifference P-value for odds ratio of gout for presence vs. absence of gout risk allele in alcohol-exposed (any alcohol intake) subgroup
  2. Adjusted for age, gender (all participants only), Townsend deprivation index, BMI, diuretics use, eGFR, high cholesterol, hypertension, cardiac problem, peripheral vascular disease, stroke, diabetes mellitus, smoking status, meat intake, fish intake, coffee intake, tea intake, fruit intake, vegetable intake, bread intake, cereal intake, and cheese intake
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Arthritis Research & Therapy

ISSN: 1478-6362

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