Fig. 1

Manhattan plots for JIA TWAS/PWAS result. The upper and lower panels show Manhattan plots for JIA TWAS and PWAS results, respectively. Each dot represents a P-value for a TWAS or PWAS association between JIA and the predicted expression level of a gene or cis-regulated plasma protein. The black and green horizontal dashed lines indicate the significance thresholds of TWAS and PWAS with Bonferroni correction (P_TWAS < 7.55 × 10⁻⁰⁷ and P_PWAS < 2.16 × 10⁻⁰⁵). Statistically significant TWAS associations of JIA are colored by tissue panels. The black dots of the lower panel indicate statistically significant PWAS associations of JIA. The names of TWAS genes and PWAS proteins with PIP > 0.2 in FOCUS are labeled