Table 1 Biological pathways significantly involved in JIA based on the TWAS associations
Gene set | Panel | P-value | FDR |
|---|---|---|---|
Wikipathway: Sulfation biotransformation reaction | GTEx: Cells - Transformed fibroblasts | 4.56 × 10−07 | 8.41 × 10−04 |
GTEx: Muscle - Skeletal | 7.58 × 10−06 | 1.12 × 10−02 | |
Reactome: Cytosolic sulfonation of small molecules | GTEx: Cells - Transformed fibroblasts | 6.11 × 10−06 | 5.63 × 10−03 |
KEGG: Sulfur metabolism | GTEx: Muscle - Skeletal | 1.16 × 10−05 | 1.12 × 10−02 |
PID: IL27 pathway | GTEx: Whole - Blood | 4.97 × 10−07 | 8.38 × 10−04 |
Reactome: Interleukin 6 family signaling | GTEx: Whole - Blood | 1.65 × 10−06 | 1.39 × 10−03 |
BioCarta: NO2IL12 pathway | GTEx: Whole - Blood | 1.10 × 10−05 | 6.17 × 10−03 |
YFS: Blood | 3.09 × 10−05 | 2.33 × 10−02 | |
BioCarta: T cell apoptosis (TCAPOPTOSIS) pathway | YFS: Blood | 9.47 × 10−06 | 1.85 × 10−02 |
BioCarta: Stathmin pathway | YFS: Blood | 3.57 × 10−05 | 2.33 × 10−02 |
BioCarta: IL17 pathway | YFS: Blood | 5.82 × 10−05 | 2.84 × 10−02 |