Fig. 2
From: Identifying functional dysregulation of NOD2 variant Q902K in patients with Yao syndrome
The 902 site of NOD2 is relatively stable during the evolutionary process. A Schematic representation of NOD2 protein structure and the location of NOD2 variant Q902K. B Evolutionary conservation of the site Q902 in NOD2 across various species using MEGA11 [17] and WebLogo [21]. C Amino acids are colored according to the vibrational entropy change upon mutation. BLUE represented a rigidification of the structure and RED represented a gain in flexibility. Images were provided by DynaMut [19]. D The structural effect of NOD2 variant Q902K was modeled based on the template from AlphaFold [18] and visualized by PyMOL Viewer software