Fig. 4
From: Identifying functional dysregulation of NOD2 variant Q902K in patients with Yao syndrome
NOD2-RIP2-MAPK inflammatory pathways were activated in PBMCs and synovial tissues from YAOS. A Western blot analysis of NOD2 signaling pathways in PBMCs from patient 1 treated with LPS (10 ng/ml) combined with MDP (10 μg/ml) stimulation. β-actin was used as a loading control. HC (n = 3). Representative images of three independent experiments were shown. B Representative images of IHC staining for abnormal NOD2 pathway activation in synovial tissues from patient 1. OA (n = 3); RA (n = 3). HC, healthy control; OA, osteoarthritis; RA, rheumatoid arthritis; IHC, immunohistochemistry