Fig. 5
From: Identifying functional dysregulation of NOD2 variant Q902K in patients with Yao syndrome
NOD2-RIP2-MAPK inflammatory pathways were activated in small intestinal mucosa tissues from YAOS. A Representative images of IHC staining for abnormal NOD2 pathway activation in small intestinal mucosa tissues from patient 1. B Quantitative results of IHC in small intestinal mucosa tissues. Positive Pixel Count was quantified as the fraction of positive to total stained pixels using Aperio ImageScope. HC (n = 3); CD (n = 3). IHC, immunohistochemistry; HC, healthy control; CD, Crohn’s disease. ns represents no statistical significance. *p < 0.05, ** p < 0.01, *** p < 0.001