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Table 2 Adjusted HRs and 95% CIs for risks of different events per trajectory of UA trajectories

From: Distinct uric acid trajectories are associated with incident cardiac conduction block

Group

Cases/total

Incidence ratea

Model 1

Model 2

Model 3

Model 4

Model 5

Cardiac conduction block

1405/67,095

3.63

     

 Low-stable

549/34,922

2.22

Ref

Ref

Ref

Ref

Ref

 Moderate-stable

662/26,679

4.32

1.30 (1.16–1.46)

1.31 (1.16–1.48)

1.30 (1.16–1.47)

1.36 (1.18–1.56)

1.20 (1.05–1.38)

 High-stable

194/5494

6.04

1.82 (1.54–2.16)

1.88 (1.57–2.24)

1.86 (1.56–2.22)

2.04 (1.61–2.59)

1.57 (1.25–1.98)

 Ptrend

  

< 0.001

< 0.001

< 0.001

< 0.001

< 0.001

Atrioventricular block

478/67,095

1.23

     

 Low-stable

170/34,922

0.84

Ref

Ref

Ref

Ref

Ref

 Moderate-stable

216/26,679

1.40

1.38 (1.12–1.70)

1.41 (1.14–1.74)

1.39 (1.12–1.72)

1.54 (1.20–1.96)

1.27 (0.99–1.62)

 High-stable

92/5494

2.86

2.81 (2.15–3.65)

2.97 (2.25–3.92)

2.90 (2.19–3.83)

3.62 (2.46–5.32)

2.38 (1.63–3.49)

 Ptrend

  

< 0.001

< 0.001

< 0.001

< 0.001

0.003

Bundle branch block

942/67,095

2.43

     

 Low-stable

382/34,922

1.89

Ref

Ref

Ref

Ref

Ref

 Moderate-stable

455/26,679

2.96

1.28 (1.11–1.47)

1.27 (1.11–1.47)

1.27 (1.10–1.47)

1.28 (1.08–1.51)

1.18 (1.00–1.40)

 High-stable

105/5494

3.27

1.42 (1.14–1.77)

1.43 (1.14–1.80)

1.43 (1.13–1.79)

1.45 (1.07–1.95)

1.21 (0.90–1.63)

 Ptrend

  

< 0.001

< 0.001

< 0.001

0.004

0.09

  1. Model 1: Adjusted for age and sex
  2. Model 2: Adjusted for variables in Model 1 plus smoking, drinking, physical activity, BMI, eGFR, hs-CRP, TG, hypertension (yes or no) and diabetes (yes or no)
  3. Model 3: Adjusted for variables in Model 2 plus antihypertensive drugs use (yes or no), hypoglycemic drugs use (yes or no) and lipid-lowering drugs use (yes or no)
  4. Model 4: Adjusted for variables in Model 3 plus UA at the first visit
  5. Model 5: Adjusted for variables in Model 3 plus UA at baseline
  6. Abbreviations: BMI body mass index, CIs confidence intervals, eGFR estimated glomerular filtration rate, HRs hazard ratio, hs-CRP high-sensitivity C reactive protein, TG triglycerides
  7. aCase per 1000 person-years