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Table 3 Sensitive analyses of the association between UA trajectories and the risk of different events

From: Distinct uric acid trajectories are associated with incident cardiac conduction block

Group

UA trajectories, HR(95%CI)

Low-stable

Moderate-stable

High-stable

Excluding participants with follow-up < 2 years (n = 64,296)

 Cardiac conduction block

Ref

1.30 (1.15–1.46)

1.86 (1.56–2.22)

 Atrioventricular block

Ref

1.40 (1.13–1.73)

2.96 (2.23–3.92)

 Bundle branch block

Ref

1.26 (1.09–1.46)

1.41 (1.12–1.78)

Excluding participants eGFR < 45 (mL/min/1.73m2) (n = 65,950)

 Cardiac conduction block

Ref

1.30 (1.15–1.46)

1.84 (1.54–2.19)

 Atrioventricular block

Ref

1.38 (1.11–1.70)

2.79 (2.10–3.70)

 Bundle branch block

Ref

1.27 (1.10–1.47)

1.43 (1.14–1.81)

Excluding participants with a history of gout (n = 66,565)

 Cardiac conduction block

Ref

1.30 (1.16–1.47)

1.82 (1.52–2.18)

 Atrioventricular block

Ref

1.39 (1.12–1.72)

2.87 (2.16–3.81)

 Bundle branch block

Ref

1.27 (1.10–1.47)

1.37 (1.08–1.73)

Excluding participants with UA data less than 4 times (n = 38,854)

 Cardiac conduction block

Ref

1.30 (1.11–1.52)

1.71 (1.36–2.16)

 Atrioventricular block

Ref

1.29 (0.98–1.71)

2.58 (1.80–3.70)

 Bundle branch block

Ref

1.30 (1.07–1.57)

1.31 (0.97–1.78)

  1. HRs were adjusted for age, sex, smoking, drinking, physical activity, BMI, eGFR, hs-CRP, TG, hypertension (yes or no), diabetes (yes or no), antihypertensive drugs use (yes or no), hypoglycemic drugs use (yes or no) and lipid-lowering drugs use (yes or no)
  2. Abbreviations: BMI body mass index, CIs confidence intervals, eGFR estimated glomerular filtration rate, HRs hazard ratio, hs-CRP high-sensitivity C reactive protein, TG triglycerides