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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Single-cell RNA sequencing of submandibular gland reveals collagen type XV-positive fibroblasts as a disease-characterizing cell population of IgG4-related disease

Fig. 1

Disease-related fibroblasts express collagen type XV in IgG4-RD submandibular gland. (A-E) Single-cell RNA sequencing analyses performed on non-hematopoietic cells from the submandibular glands of patients with IgG4-RD and controls. N = 2 for each group. (A) The UMAP plot shows that the presence of 11 clusters within the non-hematopoietic cells of the submandibular gland. (B) The characteristic gene expression patterns within each cluster, accompanied by the corresponding predicted cluster names. (C) The bar graph represents the proportions of each cluster. (D) The volcano plot shows the differentially expressed genes in fibroblasts (C1). (E) The expression of COL15A1 in each cluster. (F-G) Immunohistochemistry analysis of collagen type XV fibroblast in submandibular gland. (F) Representative images of the submandibular gland from control subjects and patients with IgG4-RD. For the IgG4-RD sample, a high magnification image is also included. (G) Cumulative data on the number of collagen type XV-positive cells is shown. (H) The differentially expressed genes between COL15A1-positive and COL15A1-negative cells

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Arthritis Research & Therapy

ISSN: 1478-6362

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