Single-cell RNA sequencing of submandibular gland reveals collagen type XV-positive fibroblasts as a disease-characterizing cell population of IgG4-related disease

Table 1 Clinical features of IgG4-RD patients and control subject analyzed using scRNA-seq and IHC

	IgG4-RD (N = 4)	Control (N = 3)
Age, median (IQR), years	62 (55.75–74)	60 (57.5–61)
Sex, female (%)	0	0
number of involved organs, median (IQR)	2 (1.75–2)	N.D.
*Serum IgG4, median (IQR), mg/dL	1333 (925–1700)	N.D.
**Serum IgG, median (IQR), mg/dL	2519 (2390–3058)	N.D.
IgG4 responder index, median (IQR)	8 (8–8.75)	N.D.

N.D.: not determined, scRNA-seq: single-cell RNA sequencing, IHC: immunohistochemistry
*Serum IgG4 normal range: 11–121 mg/dL
**Serum IgG normal range: 870–1700 mg/dL

ISSN: 1478-6362