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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Fibroblast-like synoviocytes-derived exosomal circFTO deteriorates rheumatoid arthritis by enhancing N6-methyladenosine modification of SOX9 in chondrocytes

Fig. 2

Exosomal circFTO affects the growth, migration and apoptosis of chondrocytes. (A) Representative images demonstrate the uptake of PKH26-stained exosomes by chondrocytes. (B) The expression levels of circFTO, FTO mRNA, and exosomal circFTO were assessed in RA-FLSs following the knockdown of circFTO. ***p < 0.001 vs. sh-NC. (C) Co-culturing with specific exosomes led to altered expression levels of circFTO in chondrocytes. (D) Chondrocyte viability was evaluated using a CCK-8 assay. (E) Transwell assay was performed to assess the migratory capacity of chondrocytes. (F) TUNEL assay was conducted to evaluate chondrocyte apoptosis. Data are presented as mean ± SD, n = 3; **p < 0.01, ***p < 0.001, ###p < 0.001

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Arthritis Research & Therapy

ISSN: 1478-6362

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