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Fig. 6 | Arthritis Research & Therapy

Fig. 6

From: Fibroblast-like synoviocytes-derived exosomal circFTO deteriorates rheumatoid arthritis by enhancing N6-methyladenosine modification of SOX9 in chondrocytes

Fig. 6

Exosomal circFTO regulates anabolism and catabolism of chondrocytes by targeting SOX9. (A) The expression of circFTO and SOX9 mRNA in chondrocytes following circFTO overexpression or SOX9 knockdown. (B) The expression of MMP-13 and ADAMTS-5 mRNA in chondrocytes following circFTO overexpression or SOX9 knockdown. (C) The expression of COL2 and aggrecan mRNA in chondrocytes following circFTO overexpression or SOX9 knockdown. (D) The expression of circFTO and SOX9 mRNA in chondrocytes after exosome treatment and transfection. (E) The expression of MMP-13 and ADAMTS-5 mRNA in chondrocytes after exosome treatment and transfection. (F) The expression of COL2 and aggrecan mRNA in chondrocytes after exosome treatment and transfection. Data are presented as mean ± SD, n = 3; **p < 0.011, ***p < 0.001, #p < 0.05, ##p < 0.01, ###p < 0.001, &&p < 0.01, &&&p < 0.001

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Arthritis Research & Therapy

ISSN: 1478-6362

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