Fig. 1
From: LATS2 degradation promoted fibrosis damage and rescued by vitamin K3 in lupus nephritis
Hippo pathway was involved in LN progression. A, YAP activation was found in LN biopsies and nuclear transduction was correlated with fibrotic factors α-SMA (scale bar, 20 μm). B, Knockdown of YAP alleviated the CTGF production induced by Anti-dsDNA Ab. C, Knockdown of YAP reduced profibrotic genes expressions induced by Anti-dsDNA Ab. D, Anti-dsDNA Ab promoted YAP nuclear transduction and fibrotic progression (scale bar, 2 μm). E, LATS2 but not LATS1, was downregulated in LN tubulars (scale bar, 20 μm)