Fig. 2
From: LATS2 degradation promoted fibrosis damage and rescued by vitamin K3 in lupus nephritis
LATS2 was downregulated in LN progression. A, Scheme of lupus mice sacrifice and proteinuria collection in different disease stage. B, Top: IHC staining of LATS2 in different stage of lupus mice (scale bar, 40 μm). Middle: Masson staining in different stage of lupus mice (scale bar, 20 μm). Bottom: HE staining in different stage of lupus mice (scale bar, 20 μm). C, Expression of LATS2 intensity by grayscale analysis in lupus mice (n = 8 per group). Left, 6-week. Middle, 8-week. Right, 12-week. D, Score of tubular injury in different stage of lupus mice (n = 8 per group). E, YAP localization in LN mice (scale bar, 20 μm)