Fig. 3
From: LATS2 degradation promoted fibrosis damage and rescued by vitamin K3 in lupus nephritis
Reduction of LATS2 promoted YAP activation and CTGF production in vitro and in vivo. A, LATS2, instead of LATS1, was down-regulated in renal cortex in LN mice. B, Knockdown of LATS2 promoted YAP activation and CTGF production in HK-2 cells. C, Co-localization analysis of LATS2 and YAP in LN (scale bar, 20 μm). D, Hippo pathway in LN mice cortex analyzed by western blot. E, Expression of pro-fibrotic genes in different stage of lupus mice