Fig. 4
From: LATS2 degradation promoted fibrosis damage and rescued by vitamin K3 in lupus nephritis
Restoring LATS2 alleviated renal damage in LN fibrotic progression. A, Proteinuria of LN mice (n = 6 per group). B, Expressions of YAP, and its signature downstream genes in LN mice. C, Western blot analysis of LATS2 and YAP in LN mice cortex. Overexpression of LATS2 reduced YAP activation and CTGF production. D, Top, expression of LATS2 by IHC staining. Middle, expression of a-SMA by IHC staining. Bottom, Sirus red staining (scale bar, 20 μm)