Fig. 6
From: LATS2 degradation promoted fibrosis damage and rescued by vitamin K3 in lupus nephritis
Target SIAH2 alleviated LATS2 reduction and protect renal damage in LN mice. A, Knockdown of SIAH2 decreased LATS2 degradation induced by TGF-β. B, Molecular docking analysis of vitamin K3 in SIAH2 SBD region. C, Vitamin K3 restored LATS2 levels in dose dependent. D, Vitamin K3 inhibited YAP downstream genes production induced by TGF-β. E, Vitamin K3 controlled the increase of proteinuria in LN mice (n = 8 per group). F, Vitamin K3 decreased the ACR in LN mice (n = 8 per group). G, Vitamin K3 reduced the collagen I and CTGF transcriptions in LN mice cortex in dose dependent