Fig. 4
From: Peptidoglycan in osteoarthritis synovial tissue is associated with joint inflammation
Colocalization of peptidoglycan with CD68 + macrophages and CD90 + synovial fibroblasts within synovial tissue. Shown are representative images of synovial tissue from three PG-positive patients (PG scores of 2, 3, and 4) stained for CD68 (macrophages, red), PG (green), and CD90 (synovial fibroblasts, magenta). DAPI was used as a nuclear stain. Images on left are representative of areas of PG-positive macrophages, and images on right are representative of areas of PG-positive synovial macrophages. Dotted circle indicates the approximate location of a small vessel within the inflamed synovium of Patient 3, and CD90 + cells in this image may be synovial fibroblasts, endothelial cells, or pericytes. Scale is indicated by a 10 μm white bar in each merged image