Skip to main content

Table 3 Correlation between baseline levels of urinary eicosanoids and clinical outcomes

From: Urinary prostanoids are elevated by anti-TNF and anti-IL6 receptor disease-modifying antirheumatic drugs but are not predictive of response to treatment in early rheumatoid arthritis

 

CDAI Day 0

CDAI reduction (Day 0-Week 24) *

Remission at week 24 (CDAI ≤ 2.8)*

Model 1

Model 2§

Model 1

Model 2§

Model 1

Model 2§

B

P value

B

P value

B

P value

B

P value

B

P value

B

P value

tPGEM1

-0.06

0.186

-0.06

0.240

-0.01

0.281

-0.02

0.394

-0.01

0.114

0.02

0.147

tPGDM1

0.05

0.834

0.01

0.980

0.01

0.835

0.07

0.591

-0.03

0.346

0.04

0.506

PGIM2

0.81

0.726

3.86

0.157

0.04

0.491

1.22

0.373

0.13

0.604

-0.13

0.809

TXBM2

0.46

0.826

2.09

0.477

0.01

0.849

1.02

0.311

-0.19

0.389

0.44

0.417

Total PGs1

0.04

0.274

-0.04

0.307

0.01

0.363

-0.01

0.515

-0.01

0.125

0.01

0.165

12-HETE3#

0.11

0.263

3.59

0.271

-0.09

0.268

-0.59

0.629

-0.09

0.863

0.09

0.869

LTE43#

0.03

0.785

-0.78

0.777

0.01

0.912

2.04

0.255

0.21

0.733

-0.18

0.783

  1. Generalized estimating equations (GEE) were used to calculate P values, adjustments were made as follows:
  2. ACT, Active Conventional Therapy arm; ABA, Abatacept arm; CDAI, Clinical Disease Activity Index; PGIM, 2,3-dinor-6-keto-PGF; TXBM, 2,3-dinor-TXB2;12-HETE, 12-Hydroxyeicosatetraenoic Acid; LTE4, Leukotriene E4; NSAIDs, Non-Steroidal Anti-Inflammatory Drugs; BMI, Body Mass Index
  3. 1Adjust for NSAIDs
  4. 2Adjust for NSAIDs and creatinine concentrations
  5. 3Adjust for creatinine concentrations
  6. *Adjust for CDAI day0
  7. §Adjust for BMI at baseline
  8. #Only measured in ACT and ABA arm